尹雅蕾，博士，副研究员，硕士研究生导师，大连市青年才俊，辽宁省“兴辽人才计划”博士后储备人才，中共党员，2014年获得日本京都大学药学院医疗药科学专业博士，2015年-2020年在中国科学院大连化学物理研究所医学转化中心从事科研工作，先后受聘为博士后，助理研究员。2021年受聘为大连大学附属中山医院副研究员，主要从事肿瘤靶向治疗与免疫治疗的基础与临床转化的工作。主持国家自然基金青年科学基金项目1项，参与完成不同级别的科研课题多项，申请国家专利4项，发表论文15篇，其中SCI 12篇 ,参与翻译《运动系统疾病临床解剖学》、《胃与肠》等日本先进医学相关书籍。

1）研究工作经历

2021.05-至今 大连大学附属中山医院，副研究员

2019.07-2021.4 中国科学院大连化学物理研究所 ，助理研究员

2015.01-2019.06，中国科学院大连化学物理研究所 ，博士后，合作导师：刘扬2010.10—2011.08，日本京都大学，药学院医疗药科学专业，研修生

2）主要成果

【科研项目】

[1]国家自然科学基金青年基金项目：阻断 PP2A 通路增强膀胱癌抗 PD-1 治疗的作用机制的研究，主持。

【代表性论文】

[1] Li, C., Yin, Y., Yang, Z. et al. Prognostic effect of the pretreatment prognostic nutritional index in cervical, ovarian, and endometrial cancer: a meta-analysis. BMC Women's Health， 2024，24, 464

[2] Li, XH., Zhang, Q., Li, C. et al. Examination of learning ability development through the implementation of the “autonomy-collaboration” learning mode grounded in evidence-based medicine practice. BMC Med Educ， 2024， 24, 651..

[3] 付颖; 尹雅蕾 ; 袁小林 ; 巨噬细胞-肿瘤细胞融合对肿瘤细胞迁徙与侵袭能力的影响, 国际免疫学杂志, 2023, 46(2): 129-133.

[4] Yang Liu,Yang Liu,Yunbo Jia,Jing Lv,Dan Sun, Yalei Yin, Nan Liu, Benli Su,Guangwei Sun. Generation of an induced pluripotent stem cell (iPSC) line from a diabetic patient with glucagon receptor (GCGR) p.W83X mutation. Stem Cell Research, 2022.May Volume（61）.

[5] Changqing Wu, Chaoliu Dai,Xinyu Li, Mingju Sun, Hongwei Chu , Qiuhui Xuan, Yalei Yin, Chengnan Fang, Fan Yang, Zhonghao Jiang, Qing Lv,Keqing He,Yiying Qu,Baofeng Zhao, Ke Cai, Shuijun Zhang, Ran Sun,Guowang Xu,Lihua Zhang,Siyu Sun,YangLiu. AKR1C3- dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy.Theranostics, 2022; 12(18):7681-7698..

[6] Song Gao，Liping Shan，Mo Zhang，Yan Wang，Xi Zhan，Yalei Yin， Zhonghao Jiang，Xinyi Tao，Xinyu Li，Mingliang Ye，Yang Liu.Inhibition of PP2A by LB100 sensitizes bladder cancer cells to chemotherapy by inducing p21 degradation.Cellular Oncology, (2022)45:1203–1215..

[7] Yalei Yin#, Mingju Sun, Xi Zhan, Changqing Wu, Pengyu Geng, Xiaoyan Sun, Yunsong Wu, Shuijun Zhang, Jianhua Qin, Zhengping Zhuang, Yang Liu. EGFR signaling confers resistance to BET inhibition in hepatocellular carcinoma through stabilizing oncogenic MYC.Journal of Experimental & Clinical Cancer Reserch, 2019.2.15 38(83)..

[8] 王惠国; 王嗣瑶; 韩鑫龙; 李雨桐; 袁立霞; 谭晓梅; 汤庆发; 邢学锋; 陈飞龙; 尹雅蕾 ;唐玲 ; 基于代谢组学分析青蒿琥酯治疗肝癌的作用机制, 中国实验方剂学杂志, 2019, 25(22): 78-85.

[9] Zhu Z#, Yuan G#, Fan X#, Fan Y, Yang M, Yin Y, Liu J, Liu Y, Cao X, Tian J, Xue S. The synchronous TAG production with the growth by the expression of chloroplast transit peptide-fused ScPDAT in Chlamydomonas reinhardtii. Biotechnol Biofuels. 2018 Jun 6;11:156..

[10] Yalei Yin#, Yuki Takahashi, Atsushi Hamana, Makiya Nishikawa, Yoshinobu Takakura*，Effects of transgene expression level per cell in mice livers on induction of transgene-specific immune responses after hydrodynamic gene transfer, Gene therapy， 2016,Jul;23(7):565-71..

[11] Wang Y#, Hong X, Wang J, Yin Y, Zhang Y, Zhou Y, Piao HL, Liang Z, Zhang L, Li G, Xu G, David J. Kwiatkowski*, Liu Y*. Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth. Oncogene. 2016,36(6)756-765.

[12] Yalei Yin#, Yuki Takahashi, N Ebisuura , Makiya Nishikawa, Yoshinobu Takakura*, Removal of transgene-expressing cells by transgene-specific immune response induced by sustained transgene expression, J GENE MED, 2014，16(3-4):97-106.

[13] Xu P.#, Li H.*,Liu J.,Luan Y.,Yin Y.,Bai J.,Sequence and structure prediction of RNA-dependent RNA polymerase of lily symptomless virus isolated from L. 3 ‘Casablanca’ , Arch Virol ,2011,156(6):939-943.

[14] XU Pin san*# , YL. Yin, LY. Hua,Cloning of Lily symptomless virus CP Gene and Construction of Its RNAi Vector, Acta Horticulturae Sinica,2009,36(6):885-890.

[15] Yalei Yin#, P Xu, H Liu, H Li, The clone and sequence analysis of CP gene of the LSV isolation infecting Lilium oriental hybrids in Dalian, Journal of Biotechnology, China, 2008. 10.12-10.17.

[16] Yalei Yin#, P Xu, H Liu, H Li, Molecular cloning of CP gene of LSV and construction of its RNAi expression vector, Journal of Biotechnology, China, 2008. 10.12-10.17.

【授权发明专利】

[1] 刘扬，尹雅蕾。一种突变型EGFR高表达的重组MHCC97-L肝癌细胞及构建。